Publications by authors named "S M Mehr"
Engineering Pancreatic Organoids.
Curr Cancer Drug Targets
January 2025
Experimental cell culture models that mimic the intricate features of organs offer significant potential for fundamental research and clinical applications. In order to enhance the growth of organoids, various matrices have been developed to replicate the essential character-istics of the tissue microenvironment through physical, chemical, and mechanical cues. Recent advancements in biomaterial technology have further refined the cultivation of organoids.
View Article and Find Full Text PDFRetraction notice to "Cerium oxide nanoparticles acts as a novel therapeutic agent for ulcerative colitis through anti-oxidative mechanism" [Life Sci. 278 (2021) 119500].
Life Sci
December 2024
Background: This investigation investigates the anti-inflammatory and fibrinolytic effects of a cocktail of probiotics derived from traditional dairy products in a murine model of ulcerative colitis (UC).
Materials And Methods: A mix of newly isolated probiotics containing , and was characterized and orally administered to inbred eight-week-old C57BL/6 male mice (n = 6). Clinical symptoms, pathohistological changes, and inflammatory and fibrosis markers were analyzed in the existence and absence of probiotics in colitis mice.
Article Synopsis
- Sphingosine-1-phosphate lyase insufficiency syndrome (SPLIS) is a rare genetic disorder linked to severe health issues like nephrotic syndrome, adrenal insufficiency, and various systemic symptoms, primarily caused by mutations in the SGPL1 gene.
- A study of 76 SPLIS patients found that overall survival is around 50%, with survival influenced by factors such as age at diagnosis, organ involvement, whether the patient received a kidney transplant, and specific SGPL1 genotypes.
- Children diagnosed with SPLIS nephropathy before age one have a significantly worse survival rate compared to those diagnosed after one year, highlighting the importance of early diagnosis and potential interventions.