Publications by authors named "S M Medghalchi"
The behaviour of many materials is strongly influenced by the mechanical properties of hard phases, present either from deliberate introduction for reinforcement or as deleterious precipitates. While it is, therefore, self-evident that these phases should be studied, the ability to do so-particularly their plasticity-is hindered by their small sizes and lack of bulk ductility at room temperature. Many researchers have, therefore, turned to small-scale testing in order to suppress brittle fracture and study the deformation mechanisms of complex crystal structures.
View Article and Find Full Text PDFIn the present work we present the Rotation Vector Base Line Electron Back Scatter Diffraction (RVB-EBSD) method, a new correlative orientation imaging method for scanning electron microscopy (OIM/SEM). The RVB-EBSD method was developed to study crystal mosaicity in as-cast Ni-base superalloy single crystals (SX). The technique allows to quantify small crystallographic deviation angles between individual dendrites and to interpret associated accommodation processes in terms of geometrically necessary dislocations (GNDs).
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- There is a growing need for effective anti-obesity drugs, but current options are limited; researchers are focusing on inhibiting an enzyme called GPAT to help with weight loss.
- Recent studies have shown that certain compounds, specifically 2-(alkanesulfonamido)benzoic acids, can moderate GPAT activity and lead to promising weight loss results.
- A newly synthesized compound, 4-([1,1'-biphenyl]-4-carbonyl)-2-(octanesulfonamido)benzoic acid, emerged as the strongest GPAT inhibitor, with an IC value of 8.5 µM, while modifications like adding hydroxyl or fluoro groups decreased its effectiveness.
Storage of excess calories as triglycerides is central to obesity and its associated disorders. Glycerol-3-phosphate acyltransferases (GPATs) catalyze the initial step in acylglyceride syntheses, including triglyceride synthesis. We utilized a novel small-molecule GPAT inhibitor, FSG67, to investigate metabolic consequences of systemic pharmacological GPAT inhibition in lean and diet-induced obese (DIO) mice.
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- Glycerol 3-phosphate acyltransferase (GPAT) isozymes are crucial for fat synthesis in mammals, making them targets for obesity treatments.
- The study developed and tested various cyclic bisubstrate and transition state analogs as potential GPAT inhibitors but found them less effective than a previous benzoic acid series.
- In silico docking experiments revealed that the designed compounds might be blocked by two protein loops in the enzyme’s active site, suggesting that future inhibitors should utilize planar structures to improve binding and effectiveness.