Exploring the Interplay Between Radioimmunoconjugates and Fcγ Receptors in Genetically Engineered Mouse Models of Cancer.

Fcγ receptors (FcγR) are responsible for many of the interactions between immunoglobulins (IgG) and immune cells. In biomedicine, this interplay is critical to the activity of several types of immunotherapeutics; however, relatively little is known about how FcγRs affect the in vivo performance of radiolabeled antibodies. A handful of recent preclinical studies suggest that binding by FcγR-and particularly FcγRI-can affect the pharmacokinetic profiles of Zr-labeled radioimmunoconjugates, but there are no extant studies in immunocompetent or genetically engineered mouse models of cancer.

Development of common metrics for donation attitude, subjective norm, perceived behavioral control, and intention for the blood donation context.

Background: The Theory of Planned Behavior has been widely used in blood donation research, but the lack of uniform, psychometrically sound measures makes it difficult to draw firm conclusions or compare results across studies. Accordingly, the goal of this study was to develop such measures of donation attitude, subjective norm, perceived behavioral control, and intention.

Study Design And Methods: Exploratory and confirmatory factor analyses (CFAs) were conducted on survey responses collected from college students (n = 1080).

A Web-based approach to blood donor preparation.

Background: Written and video approaches to donor education have been shown to enhance donation attitudes and intentions to give blood, particularly when the information provides specific coping suggestions for donation-related concerns. This study extends this work by comparing Web-based approaches to donor preparation among donors and nondonors.

Study Design And Methods: Young adults (62% female; mean [±SD] age, 19.

Routine pre-cesarean Staphylococcus aureus screening and decolonization: a cost-effectiveness analysis.

Objectives: To estimate the economic value of screening pregnant women for Staphylococcus aureus carriage before cesarean delivery.

Study Design: Computer simulation model.

Methods: We used computer simulation to assess the cost-effectiveness, from the third-party payer perspective, of routine screening for S aureus (and subsequent decolonization of carriers) before planned cesarean delivery.

The potential economic value of a 'universal' (multi-year) influenza vaccine.

Background: Limitations of the current annual influenza vaccine have led to ongoing efforts to develop a 'universal' influenza vaccine, i.e., one that targets a ubiquitous portion of the influenza virus so that the coverage of a single vaccination can persist for multiple years.