[An analysis of the specificity of anti-Mycobacterium monoclonal antibodies and of the chemical nature of the antigenic determinants with which they react].

Seven hybridomas of BALB/c mice producing monoclonal antibodies (mAb) against M. tuberculosis H37Rv have been obtained. The mAb acted against M.

[Immunity and resistance in experimental tuberculosis in mice exposed to various environmental factors].

CBA mice maintained on the chow and water with either normal or deficient in particular trace elements were infected with M. tuberculosis H37Rv. Mice with deficiency of silicon showed a tendency for decreased survival, had less active DTH response to tuberculin and proliferation in vitro upon stimulation by mycobacterial antigens and nonspecific mytogens than mice on balanced diet, higher levels of specific IgG.

[Modulation of the course of experimental tuberculosis in mice by in vivo administration of monoclonal antibodies to interleukin-2, gamma-interferon and interleukin-4].

The impact of the in vivo administration of monoclonal antibodies against cytokines on the development of a pathological process in mice infected with Mycobacterium tuberculosis H37Rv-infected mice. The susceptibility to fatal experimental tuberculosis, the level of DTH to mycobacterial antigens, the production of specific antimycobacterial IgG and IgM, T-cell proliferative responses to M. tuberculosis H37Rv antigens.