Efficacy of iron replacement in pulmonary hypertension: A systematic review.

The systematic review summarizes the current evidence on the efficacy and safety of iron replacement in patients with pulmonary hypertension (PH). A systematic literature search was conducted in electronic databases like PubMed, Scopus, Web of Science, and Embase up to April 2024. Eligible studies investigating iron replacement therapy in pulmonary hypertension patients were included in the review.

Biogeochemical cycling of iodine in the Bay of Bengal: A comparison with the Arabian Sea.

Iodine is a redox-sensitive element and a potential oxidant for the respiration of organic matter. Here we report the spatial variation of dissolved iodine in the Bay of Bengal (BoB) oxygen minimum zone (OMZ) and compare it with that of the Arabian Sea (AS). Subsurface iodide peaks were observed in the upper boundary of the OMZ, representing 20 to 70 % of the total iodine budget in the BoB.

Increasing Utilization of Extended Oral Antibiotic Prophylaxis Following Total Knee Arthroplasty From 2010 to 2022.

Background: Extended oral antibiotic (EOA) prophylaxis has been shown to reduce rates of periprosthetic joint infection in high-risk patients following total knee arthroplasty (TKA). Although national societies' recommendations against their use and clinical efficacy remain controversial, the increase in the literature surrounding EOA prophylaxis suggests a potential change in practice patterns that may warrant the creation of national guidelines. The purpose of this study was to investigate the trends in the utilization of EOA prophylaxis following TKA from 2010 to 2022.

Metformin use and its association with various outcomes in COVID-19 patients with diabetes mellitus: a retrospective cohort study in a tertiary care facility.

Background: Evidence shows that diabetes raises the probability of contracting COVID-19 and associated complications. We hypothesize that metformin, being pleiotropic, may improve COVID-19 in diabetics.

Methods: A retrospective cohort study was conducted with 421 COVID-19 patients with diabetes, hospitalized between 1st April 2020 and 31st March 2022 in a tertiary-care hospital.

Systemic immune inflammatory response index (SIIRI) in acute myocardial infarction.

Background: Different treatment approaches exist for non-ST elevation acute coronary syndrome (ACS) patients. This study assessed the systemic immune inflammatory response index (SIIRI) for its prognostic value and incremental clinical utility in determining optimal timing for percutaneous coronary intervention (PCI) in non-ST elevation myocardial infarction (NSTEMI) patients, particularly when troponin levels are initially negative.

Methods: This study included 1270 ACS patients: 437 STEMI, 422 NSTEMI, and 411 unstable angina.