[The structural-functional properties of light and dark hepatoma cells].

Morphofunctional analysis of the light and dark solid hepatoma cells of mouse line 22a C3HA and culture of human hepatoma has shown that in both hepatomas the dark cells when compared with the light ones possess increased electronic density of hyaloplasm, and besides the dark cells of solid tumor line have a well-developed endoplasmic reticulum and numerous mitochondria. Both types of cells are able to incorporate labelled RNA and DNA precursors and also to divide themselves mitotically.

[The structural and functional properties of light and dark mouse hepatocytes].

The morphofunctional analysis of the light and dark hepatocytes of mouse C3HA line has shown that the dark cells have increased electronic density of hyaloplasm in contrast to the light ones. The light hepatocytes predominate among tetra- and octaploid cells. Both cell types are able to incorporate [3H] uridine and [3H] thymidine.

[Light optical and electron microscopic studies of the tumor cells in rats exposed to vinblastine against a background of increased activity of the anticoagulating system].

It is shown that the damage of sarcoma 45 cells at different stages of cell life cycle occurs under the effect of vinblastine treatment against a background of higher activity of the blood anticoagulating system. A decrease in the mitotic activity, mitosis accumulation in prophase and especially in the metaphase as well as essential changes in the interphase cell ultrastructure are detected.

[Effect of vinblastine during high activity of the anticoagulating system on the growth of sarcoma 45 in rats and several blood indicators in animals with tumors].

The strong depressive effect of vinblastine on the rat sarcoma 45 growth and intensification of this effect by the combination of vinblastine treatment with the activation of the blood anticoagulating system (BAS) were found. Vinblastine had no negative effect on the BAS activation process and induced no persistent changes in the qualitative content of leucocytes in the peripheral blood.

[Ratio of "light" and "dark" cells in heterogineous cell populations of experimental tumors and their metastases].

The number of undifferentiated "light" cells and of differentiated "dark" cells was calculated in heterogeneous tumour cell populations of sarcoma 45 and Walker carcinosarcoma of rats at various stages of tumour growth and metastases.