Publications by authors named "S M Knipe"
Background: Achondroplasia, the most prevalent skeletal dysplasia, stems from a functional mutation in the fibroblast growth factor receptor 3 gene, leading to growth impairment. This condition presents multifaceted medical, functional and psychosocial challenges throughout childhood, adolescence and adulthood. Current management strategies aim to minimise medical complications, optimise functional capabilities and provide comprehensive supportive care.
View Article and Find Full Text PDF5-Hydroxytryptamine (5-HT; serotonin) has been implicated in the perception of exercise-induced fatigue. Sumatriptan is a selective 5-HT(1B/D) receptor agonist which does not cross the blood-brain barrier. The aim of the present study was to determine the effect of sumatriptan on exercise capacity.
View Article and Find Full Text PDFMouse liver cells in primary culture were evaluated by high-resolution light microscopy (HRLM) and transmission electron microscopy (TEM). Cells after 2 hours of culture in L-15 medium supplemented with 10% fetal bovine serum were spherical in shape, and were either individual or in small clusters of up to ten cells. Following 1 day in culture, hepatocytes were flattened and usually found in groups.
View Article and Find Full Text PDFArticle Synopsis
- The study examined how rat esophageal epithelial cells can be biologically transformed when exposed to a carcinogen, BMNA, in a controlled environment.
- Cells were treated with different concentrations of BMNA, and those exposed to the carcinogen showed increased ability to grow and establish cell lines, which was directly related to the dose received.
- Electron microscopy and immunofluorescence confirmed that the treated cells retained characteristics of esophageal epithelial cells and, importantly, certain cell lines formed tumors resembling squamous cell carcinomas when injected into compatible recipients.