Publications by authors named "S M Kielbasa"
Article Synopsis
- Tumours, especially in follicular lymphoma, show significant genetic and transcriptional diversity that influences cancer development and treatment strategies.
- The study introduces CaClust, an advanced model that combines various genomic data types to better understand tumor evolution and how genotypes translate into phenotypes.
- CaClust demonstrates improved performance over existing models and offers insights into mutations driving the disease, potential treatment targets, and confirms findings through single-cell analysis.
Innate mononuclear phagocytic system (MPS) cells preserve mucosal immune homeostasis. We investigated their role at nasal mucosa following allergen challenge with house dust mite. We combined single-cell proteome and transcriptome profiling on nasal immune cells from nasal biopsies cells from 30 allergic rhinitis and 27 non-allergic subjects before and after repeated nasal allergen challenge.
View Article and Find Full Text PDFBackground & Aims: Improving clinical management of early stage colorectal cancers (T1CRCs) requires a better understanding of their underlying biology. Accumulating evidence shows that cancer-associated fibroblasts (CAFs) are important determinants of tumor progression in advanced colorectal cancer (CRC), but their role in the initial stages of CRC tumorigenesis is unknown. Therefore, we investigated the contribution of T1CAFs to early CRC progression.
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