[Investigation of the role of Zn2+ and zinc-containing proteins in the pathogenesis of bone inflammmation (the case of periodontitis)].

The levels of Ag, Al, Bi, Co, Cr, Fe, Mo, Si in osseous tissue of periodontium of domestic cats decreased in case of periodontitis in comparision with those of a healthy animals. At the same time the level of Zn increased dramatically. The level of tagged [14C] glycine in protein of bones of periodontium increased twofold and [35S] methionine 1,54 times which is explained by the fact of predominance of I type collagen in which one third of amino acids is represented by glycine while sulfur-containing amino acids are virtually absent.

[A new view on pathochemical mechanisms of prolonged peritoneal dialysis].

New data on etiology, pathogenesis, clinics, quantity estimation, treatment and complications of peritoneal dialysis are observed. The role of aquaporine, nitric oxide, NO-synthase, inflammation and sepsis markers (procalcitonine, C-reactive protein) in pathochemical mechanism of peritoneal dialysis is discussed.

Study of drug transport between the blood and lymph in the predominant direction.

Our method for evaluating the time course and intensity of antibiotics and other drugs transport in the predominant direction between the blood and lymph in humans promotes a more objective evaluation of drug circulation mechanisms, which is essential for determining the time of their repeated administration and route of administration. Calculation of the lymph/blood difference coefficient, based on parallel repeated measurements of the drug concentration in the lymph and blood, and of the lymph/blood coefficient provides complete data on the direction and time course of drug transport between the lymph and blood in the predominant direction.