Publications by authors named "S M Jenkins"
Article Synopsis
- The study examined 33 severe COVID-19 patients who underwent a novel hemoperfusion therapy using the Seraph100 filter, aiming to reduce viral RNA levels and markers of inflammation.
- Results showed that while the initial levels of SARS-CoV-2 RNA were generally low and did not significantly change post-treatment, five inflammatory protein analytes exhibited notable decreases, indicating some therapeutic effect on inflammation and endothelial damage.
- The conclusion highlighted that Seraph 100 did not effectively lower viral RNA levels, but it did successfully reduce several inflammatory markers in the blood of these patients.
Objective: Early antivenom administration is essential for effective treatment. We investigated the delays in antivenom administration.
Methods: We reviewed snakebites from the Australian Snakebite Project (2006-2021) given antivenom, presenting to hospital within 12 h.
Role of radicals in the reaction of oxygen difluoride with monohydrogenated silicon.
Phys Chem Chem Phys
January 2025
We present first-principles molecular dynamics simulations of oxygen difluoride impinging upon the monohydrogenated Si{001}(2 × 1) surface. Adsorption occurred in fewer than 10% of our computed trajectories, but in each reactive case the initial step involved partial dissociation to yield an adsorbed fluorine atom and a free oxygen monofluoride radical. In one trajectory, the adsorbed fluorine atom displaced a hydrogen atom into an unusual Si-H-Si bridge position, consistent with three-centre two-electron bonding.
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- Newer HIV-1 maturation inhibitors, like VH3739937 (VH-937), have shown promise as effective antiretroviral treatments in clinical settings.
- VH-937 features a 4-cyanopyridyl ether design that is a step up from earlier inhibitors, leading to a better antiviral profile and effectiveness against the A364V mutation, a common resistance issue.
- Due to its improved pharmacokinetic properties, VH-937 has the potential for infrequent dosing, with initial human studies supporting the possibility of once-weekly administration.
Background: African Americans have a higher prevalence of cardiovascular risk factors, leading to higher cardiovascular disease mortality than White adults. Our culturally tailored mobile health (mHealth) lifestyle intervention () has previously demonstrated efficacy in promoting ideal cardiovascular health in African Americans.
Methods: We conducted a secondary analysis from a cluster randomized controlled trial among African-Americans from 16 churches in Minnesota that compared the to a delayed intervention control group.