Identification of Natural Terpenoid Compounds as Potential Inhibitors of Nucleoprotein of Influenza A Virus using in silico Approach: ADMET, Molecular Docking, and Molecular Dynamic Simulation.

Background: We continue to struggle with the prevention and treatment of the influenza virus. The 2009 swine flu pandemic, caused by the H1N1 strain of influenza A, resulted in numerous fatalities. The threat of influenza remains a significant concern for global health, and the development of novel drugs targeting these viruses is highly desirable.

Validation, bias assessment, and optimization of the UNAFIED 2-year risk prediction model for undiagnosed atrial fibrillation using national electronic health data.

Background: Prediction models for atrial fibrillation (AF) may enable earlier detection and guideline-directed treatment decisions. However, model bias may lead to inaccurate predictions and unintended consequences.

Objective: The purpose of this study was to validate, assess bias, and improve generalizability of "UNAFIED-10," a 2-year, 10-variable predictive model of undiagnosed AF in a national data set (originally developed using the Indiana Network for Patient Care regional data).

An Assessment of Multipollutant Exposures Using Silicone Wristbands Among Bangladeshi Youth.

Residents of Bangladesh are exposed to numerous chemicals due to local industries, including dyeing mills, cotton mills, and the use of biomass in daily cooking. It is, therefore, important to characterize the exposome and work to identify risk factors of exposure. We used silicone wristband passive samplers to evaluate exposure to volatile and semi-volatile organic compounds in a sample of 40 children in the Araihazar upazila of Bangladesh.

Advancements in synthesis, immobilization, characterization, and multifaceted applications of silver nanoparticles: A comprehensive review.

Silver nanoparticles (AgNPs) have attracted significant interest in recent years owing to their unique physicochemical properties, including antimicrobial reduction capabilities, photocatalytic activity, self-cleaning features, superhydrophobicity, and electrical conductivity. Their characteristics render them highly advantageous for various textile, electronics, food and agriculture, water treatment, and biomedical applications. This detailed analysis explores the recent benefits and drawbacks of various synthesis methods, immobilization techniques, and characterization of AgNPs while emphasizing novel strategies that improve their functionality across different substrates.

Structure-based interaction study of Samaderine E and Bismurrayaquinone A phytochemicals as potential inhibitors of KRas oncoprotein.

Ras is identified as a human oncogene which is frequently mutated in human cancers. Among its three isoforms (K, N, and H), KRas is the most frequently mutated. Mutant Ras exhibits reduced GTPase activity, leading to the prolonged activation of its conformation.