Publications by authors named "S M Hossein Karimian"
New derivatives 6a-m with benzimidazole-indole-amide scaffold were developed, synthesized, and assessed for potential inhibitory effects on α-glucosidase and acetylcholinesterase (AChE). These compounds were synthesized by various amine derivatives. With the exception of two compounds, the α-glucosidase inhibitory activities of the title derivatives were more than that of the positive control acarbose.
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- Blood-based biomarkers like plasma neurofilament light chain (pNfL) are vital for understanding Alzheimer's disease (AD) and their relationship with brain imaging techniques, particularly tensor-based morphometry (TBM).
- The study analyzed data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) involving 567 participants to explore how polygenic hazard score (PHS) influences the link between pNfL and TBM findings.
- Results indicated that PHS mediates the relationship between pNfL levels and TBM measures in AD, suggesting that PHS should be considered in future research on AD biomarkers and imaging outcomes.
Article Synopsis
- Dementia, particularly vascular dementia (VD), is influenced by factors like cerebrovascular disease, which increases histone-3 lysine-9 dimethylation (H3K9me2) and hinders protective gene expressions.
- A study using an in vivo VD model tested the effects of the H3K9me2 inhibitor BIX01294, which showed significant improvements in neurological deficits and memory functions.
- BIX01294 treatment elevated neuroprotective factors while reducing apoptosis levels and amyloid beta accumulation, suggesting it may help prevent neuronal loss in dementia.
Article Synopsis
- Monkeypox (Mpox) is an Orthopoxvirus causing skin blisters with a mortality rate of 0-10% and has seen an increase in cases since the end of global smallpox vaccinations.
- This review discusses updates on Mpox's transmission, symptoms, diagnosis, prevention, and treatment, highlighting the role of AI in predicting the disease.
- Key prevention strategies involve PCR testing for early detection, vaccination with JYNNEOS and ACAM2000, and minimizing contact with symptomatic individuals, similar to STI prevention practices.