Publications by authors named "S M Helmke"
Aims: Transthyretin cardiomyopathy (ATTR-CM) is characterized by episodes of worsening heart failure (WHF) which can include heart failure (HF) hospitalizations or urgent unplanned visits for administration of intravenous diuretics. WHF characterized by outpatient intensification of oral loop diuretics is common yet its prognostic implications for ATTR-CM patients relative to other WHF events remains unclear. We assessed how WHF characterized by outpatient diuretic intensification (ODI) relates to mortality in this population.
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- - Transthyretin cardiac amyloidosis (ATTR-CA) is more commonly diagnosed in older men, but research indicates that women may be underrepresented in previous statistics regarding its prevalence.
- - The SCAN-MP study used nuclear imaging to assess ATTR-CA in older Black and Caribbean Hispanic individuals, revealing that this cohort had a higher percentage of women (31.3%) compared to a referral center (13.3%).
- - Women in the SCAN-MP cohort displayed a less severe form of the disease, indicated by higher heart function and lower heart mass, suggesting that targeted identification in women is essential to address existing sex disparities in ATTR-CA diagnoses.
Background: The accuracy of current criteria for ruling out large oesophageal varices (LEV) and other endoscopic lesions of portal hypertension (PH) may be compromised by obesity and MASLD/MASH.
Aims: In the US multicentre SHUNT-V study, we evaluated the disease severity index (DSI) for detecting LEV and other lesions of PH at endoscopy.
Methods: Subjects were adults with compensated cirrhosis scheduled for endoscopy to screen for varices.
Background And Aims: We quantified hepatic functional impairment using quantitative function tests and linked severity of functional impairment to liver-related complications and outcome in primary sclerosing cholangitis.
Methods: Forty-seven patients had baseline testing, and 40 were retested after 1 year. For each test, cholates labeled with cold, nonradioactive isotopes were administered orally (DuO, SHUNT tests) and intravenously (SHUNT test), and blood was analyzed at 20 and 60 minutes (DuO), or 0, 5, 20, 45, 60, and 90 minutes (SHUNT).
Background: Current methods for evaluating liver health rely on nonspecific blood tests, elastography surrogates for fibrosis, and invasive procedures, none of which directly measure liver function and physiology. Herein we present the analytical validation of a unique, highly sensitive LC-MS/MS assay and dual-sample oral (DuO) cholate challenge test to reliably quantify serial serum concentrations of cholate isotopes administered to patients with liver diseases. The clearance of administered cholate isotopes measured by the assay provides information about liver function and physiology.
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