Publications by authors named "S M Hassanein"
Objectives: Intravenous tenecteplase (TNK) is increasingly used to treat adult patients with acute arterial ischemic stroke, but the risk profile of TNK in childhood stroke is unknown. This study aims to prospectively gather safety data regarding TNK administration in children.
Methods: Since December 2023, a monthly email survey was sent to participants recruited from the International Pediatric Stroke Study and Pediatric Neurocritical Care Research Group querying recent experience with TNK in childhood stroke.
Precursor messenger RNA (pre-mRNA) is processed into its functional form during RNA polymerase II (Pol II) transcription. Although functional coupling between transcription and pre-mRNA processing is established, the underlying mechanisms are not fully understood. We show that the key transcription termination factor, RNA exonuclease Xrn2 engages with Pol II forming a stable complex.
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- Infraorbital ethmoidal air cells (IOEAc) are a type of ethmoidal cells located beneath the orbit, showing significant anatomical variation in humans.
- A study involving 1260 CT scans aimed to identify and classify these variations, noting the presence of IOEAc in 173 cases (13.7%).
- The new classification system categorized the air cells into five main types with various subtypes, enhancing understanding for clinical practice and future research.
Article Synopsis
- Mitochondria are vital for energy production and play important roles in cellular processes and stress responses, particularly in plants facing environmental challenges like drought.
- This study investigates RNA editing patterns in distinct wheat cultivars under drought conditions to better understand how plants adapt to stress.
- Results indicate significant RNA editing, especially C-to-T conversions, affecting protein structure and regulatory functions, with differences in responses between drought-tolerant and sensitive wheat varieties.
Background: Recent discoveries have illustrated that Lin28A is an oncogene in various cancers, particularly acute myeloid leukemia (AML). The upregulation of Lin28A can actively contribute to tumorigenesis and migration processes in multiple organs. Hence, the inhibition of Lin28A can be achieved by applying phytochemical herbals and targeting Lin28A protein using a computer-aided drug design (CAAD) approach.
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