Publications by authors named "S M Haeryfar"
Present bladder cancer therapies have relatively limited therapeutic impact and account for one of the highest lifetime treatment costs per patient. Therefore, there is an urgent need to explore novel and optimized treatment strategies. The present study investigated the effects of inhibiting endogenous hydrogen sulfide (HS) production on bladder cell viability and in vivo tumor progression.
View Article and Find Full Text PDFThe Canadian Society for Immunology (CSI) established a formal Equity, Diversity, and Inclusion (EDI) Committee with the goal of providing EDI advocacy and leadership within the CSI, as well as in the broader scientific community. A first task of this committee was to review the publicly available historical data on gender representation within the CSI's membership, leadership, award recipients, and conference chairs/presenters as a step in establishing a baseline reference point and monitoring the trajectory of future success in achieving true inclusion. We found that, except for overall membership and a specific subset of awards, all categories showed a historical bias toward men, particularly prior to 2010.
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- Fecal microbiota transplantation (FMT) is being explored as a way to enhance the effectiveness of immune checkpoint inhibitors in treating advanced melanoma, but its use in initial treatments was previously untested.
- A phase I trial involving 20 untreated melanoma patients showed that FMT combined with PD-1 inhibitors (nivolumab or pembrolizumab) was safe, with no severe adverse events from FMT alone, although some patients experienced immune-related side effects.
- The trial found a 65% objective response rate, with changes in gut microbiome observed, indicating that successful treatments were linked to beneficial bacterial changes after FMT, suggesting that this approach should be studied further in conjunction with immune therapies.
Mucosa-associated invariant T (MAIT) cells are MR1-restricted, innate-like T lymphocytes with tremendous antibacterial and immunomodulatory functions. Additionally, MAIT cells sense and respond to viral infections in an MR1-independent fashion. However, whether they can be directly targeted in immunization strategies against viral pathogens is unclear.
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