Investigation of the female genital tract microbiome and its association with hydrosalpinx in women undergoing salpingectomy.

Objective: To describe the microbiome of the vagina and fallopian tubes (FT) and its relation with hydrosalpinx.

Methods: Case-control study was conducted in women who underwent salpingectomy for hydrosalpinx (case) or other indications (controls). Samples were obtained during surgery and subjected to 16S rRNA amplicon sequencing, and analyses of alpha diversity and beta diversity measures were compared between sites and groups.

Should Older Patients Accept a High KDPI Kidney or Wait? A National Data Analysis of Matched Cohorts.

Objective: This study addressed whether kidney transplant (KTx) candidates, ages 60+, should accept a high KDPI kidney and differences when considering a high (>85% vs low (<85%) KDPI KTx.

Summary/background Data: To date, there is limited survival data to guide decision-making for patients aged 60 years and older who are faced with the choice of accepting a high KDPI kidney or remaining on the waitlist.

Methods: Propensity-matched cohort study using data from United Network on Organ Sharing (2014-2021).

Intraocular Inflammation After Aflibercept Prefilled Syringe and Vial Injections.

In this observational cohort study, incidence of intraocular inflammation following intravitreal injection in the Vestrum Health database was significantly lower with aflibercept 2-mg (EYLEA) prefilled syringes versus vials from 2020 to 2022 (P < 0.0001).

Real-time inference for binary neutron star mergers using machine learning.

Mergers of binary neutron stars emit signals in both the gravitational-wave (GW) and electromagnetic spectra. Famously, the 2017 multi-messenger observation of GW170817 (refs. ) led to scientific discoveries across cosmology, nuclear physics and gravity.

Bacteriophage therapy for multidrug-resistant infections: current technologies and therapeutic approaches.

Bacteriophage (phage) therapy has emerged as a promising solution to combat the growing crisis of multidrug-resistant (MDR) infections. There are several international centers actively engaged in implementation of phage therapy, and recent case series have reported encouraging success rates in patients receiving personalized, compassionate phage therapy for difficult-to-treat infections. Nonetheless, substantial hurdles remain in the way of more widespread adoption and more consistent success.