Publications by authors named "S M Glynn"
Background: Risk-benefit tradeoffs between restrictive versus liberal red blood cell transfusion strategies may vary across individuals. This exploratory analysis aimed to derive and evaluate individualized treatment effects of defined transfusion strategies in patients with acute MI and anemia with the goal of minimizing adverse cardiovascular outcomes.
Methods: This study analyzed 3,447 (98.
Are we there yet? Closing the gap of prostate cancer presentation disparities in Ireland.
Arch Public Health
November 2024
Introduction: The Irish Prostate Cancer Outcomes Research (IPCOR) Study collected longitudinal data on men newly diagnosed with Prostate Cancer (PC). Understanding the nuances of disease presentation is essential, considering the high incidence of PC in Ireland. This study aims to characterise disease presentation features, identify factors related to socio demographic disparities in presentation following opportunistic screening, and shed light on potential inequality challenges within Ireland's healthcare structure.
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- The study focuses on specific clusters of CD8+ T cells, categorized as CD8-NOS2+COX2+ and CD8-NOS2-COX2+, which play a significant role in the immune response to tumors.
- These unique cellular environments affect the spatial structure of CD8+ T cell interactions within tumors and can influence patient outcomes.
- The findings suggest that existing treatments, like NOS inhibitors and NSAIDs, could potentially target these cellular neighborhoods to improve cancer therapy.
Study Objective: To determine if baseline cytokines/chemokines and their changes over postoperative days 0-2 (POD0-2) predict acute and chronic postsurgical pain (CPSP) after major surgery.
Design: Prospective, observational, longitudinal nested study.
Setting: University-affiliated quaternary children's hospital.
Examining Hemin and its Derivatives: Induction of Heme-Oxygenase-1 Activity and Oxidative Stress in Breast Cancer Cells through Collaborative Experimental Analysis and Molecular Dynamics Simulations.
J Med Chem
September 2024
Article Synopsis
- * The study investigates the effects of hemin and its derivatives on breast cancer cell behaviors, including migration, apoptosis indicators, mitochondrial function, and ROS production.
- * Molecular simulations reveal that heme has a stronger binding affinity to HOX-1 compared to its derivatives, and the interactions help shed light on HOX-1 regulation and oxidative stress management, which could inform new cancer treatment strategies.