Publications by authors named "S M Gevao"
Article Synopsis
- Researchers found that the LARGE gene is crucial for how Lassa virus binds and enters human cells, linking it to natural selection in populations in Nigeria, particularly the Yoruba.
- They suggest that the rise of diseases like Lassa fever is more about increased detection capabilities than the emergence of new viruses, indicating humans may have been exposed to these pathogens for longer than thought.
- This groundwork inspired the Sentinel project, aimed at early detection and characterization of pathogens globally through its core strategies of detection, information sharing, and empowering public health systems to enhance pandemic preparedness.
Neutralizing antibody function provides a foundation for the efficacy of vaccines and therapies. Here, using a robust in vitro Ebola virus (EBOV) pseudo-particle infection assay and a well-defined set of solid-phase assays, we describe a wide spectrum of antibody responses in a cohort of healthy survivors of the Sierra Leone EBOV outbreak of 2013-2016. Pseudo-particle virus-neutralizing antibodies correlated with total anti-EBOV reactivity and neutralizing antibodies against live EBOV.
View Article and Find Full Text PDFObjectives: In Sierra Leone, very little data are available on hepatitis B virus (HBV) and hepatitis C virus (HCV) prevalence. Blood donor screening permits estimation of the prevalence of transfusion transmissible infections in a general open population. We analyzed blood donor data in Sierra Leone to estimate national viral hepatitis prevalence and identify risk factors for hepatitis infection among the donor population.
View Article and Find Full Text PDFTo end the largest known outbreak of Ebola virus disease (EVD) in West Africa and to prevent new transmissions, rapid epidemiological tracing of cases and contacts was required. The ability to quickly identify unknown sources and chains of transmission is key to ending the EVD epidemic and of even greater importance in the context of recent reports of Ebola virus (EBOV) persistence in survivors. Phylogenetic analysis of complete EBOV genomes can provide important information on the source of any new infection.
View Article and Find Full Text PDFThe 2013-2016 West African epidemic caused by the Ebola virus was of unprecedented magnitude, duration and impact. Here we reconstruct the dispersal, proliferation and decline of Ebola virus throughout the region by analysing 1,610 Ebola virus genomes, which represent over 5% of the known cases. We test the association of geography, climate and demography with viral movement among administrative regions, inferring a classic 'gravity' model, with intense dispersal between larger and closer populations.
View Article and Find Full Text PDF