In Silico Prediction of Alkaline Phosphatase Interaction with the Natural Inhibitory 5-Azaindoles Guitarrin C and D.

The natural 5-azaindoles, marine sponge guitarrin C and D, were observed to exert inhibitory activity against a highly active alkaline phosphatase (ALP) CmAP of the PhoA family from the marine bacterium , with IC values of 8.5 and 110 µM, respectively. The superimposition of CmAP complexes with -nitrophenyl phosphate (NPP), a commonly used chromogenic aryl substrate for ALP, and the inhibitory guitarrins C, D, and the non-inhibitory guitarrins A, B, and E revealed that the presence of a carboxyl group at C6 together with a hydroxyl group at C8 is a prerequisite for the inhibitory effect of 5-azaindoles on ALP activity.

Effectiveness of the quercetin use in patients with COVID-19 with concomitant type 2 diabetes mellitus.

Objective: Aim: To conduct a comparative analysis of the effectiveness of basic therapy and basic therapy with the inclusion of quercetin in patients with COVID-19 with concomitant type 2 diabetes.

Patients And Methods: Materials and Methods: There were examined 60 patients with COVID-19 with concomitant T2DM. Upon admission into the hospital and again after 10 days, serum levels of interleukin-6, C-reactive protein, procalcitonin, ferritin, endothelin-1 were determined, and capillaroscopy of the nail plate was performed.

Lyme borreliosis in Ivano-Frankivsk district, Ukraine: a epidemiological and clinical characteristics (2000-2022).

Objective: Aim: To give epidemiological and clinical characteristics of the morbidity of Lyme borreliosis in Ivano-Frankivsk region for the period of 2000-2022 years.

Patients And Methods: Materials and Methods: There were used annual reports (form №1) from the State Institution "Ivano-Frankivsk Regional Center for Disease Control and Prevention of the Ministry of Health of Ukraine" and 200 of "Medical records of inpatients" (form 003/о) of the Ivano-Frankivsk Regional Clinical Infectious Diseases Hospital for 2000-2022 years.

Results: Results: The morbidity of Lyme borreliosis in the Ivano-Frankivsk region has been permanently increasing since 2000.

Stonikacidin A, an Antimicrobial 4-Bromopyrrole Alkaloid Containing L-Idonic Acid Core from the Northwestern Pacific Marine Sponge .

Stonikacidin A (), the first representative of a new class of 4-bromopyrrole alkaloids containing an aldonic acid core, was isolated from the marine sponge . The compound is named in honor of Prof. Valentin A.

Squeezed light from an oscillator measured at the rate of oscillation.

Sufficiently fast continuous measurements of the position of an oscillator approach measurements projective on position eigenstates. We evidence the transition into the projective regime for a spin oscillator within an ensemble of 2 × 10 room-temperature atoms by observing correlations between the quadratures of the meter light field. These correlations squeeze the fluctuations of one light quadrature below the vacuum level.