Publications by authors named "S M Enger"
Background: Orthotopic models offer a more accurate representation of colorectal cancer (CRC) compared to subcutaneous models. Despite promising results from the reported intra-rectal models, establishing a standardized method for CRC research remains challenging due to model variability, hindering comprehensive studies on CRC pathogenesis and treatment modalities, such as brachytherapy. This study aimed to establish a standardized workflow for an orthotopic intra-rectal animal model to induce the growth of colorectal adenocarcinoma in male and female mice.
View Article and Find Full Text PDFObjectives: The objective of this study was to assess the quality of ECG recordings and the concordance between the automatic detection of cardiac arrhythmia episodes by a patch ECG and an insertable cardiac monitor.
Design: Prospective cohort study.
Setting And Participants: Endurance athletes diagnosed with paroxysmal atrial fibrillation (AF) and no other relevant comorbidities participating in a randomised controlled trial on the effects of training adaption.
Background: Coronary artery disease is the most common form of cardiovascular disease. It is caused by excess plaque along the arterial wall, blocking blood flow to the heart (stenosis). A percutaneous coronary intervention widens the arterial wall with the inflation of a balloon inside the lesion area and leaves behind a metal stent to prevent re-narrowing of the artery (restenosis).
View Article and Find Full Text PDFArticle Synopsis
- A study investigates discrepancies in dosimetry of the Xoft electronic high-dose rate brachytherapy due to variability in source manufacturing, aiming to develop a software tool called E-Brachy for better characterization.
- E-Brachy employs the Geant4 Monte Carlo toolkit, using Python for geometry integration and advanced simulation techniques to generate x-ray spectra from electrons, which are then compared to standards from NIST.
- Results show that E-Brachy successfully generates a spectrum similar to NIST measurements, suggesting potential improvements in dosimetric accuracy for clinical applications.
Article Synopsis
- Pancreatic cancer has limited treatment options, and a new method called Alpha DaRT, using alpha-particle radiation therapy, is being tested to improve outcomes.
- A study evaluated the safety and feasibility of using EUS-guided Alpha DaRT to treat patients with advanced, inoperable pancreatic cancer, with procedures conducted successfully between March and September 2023.
- Results showed that while some adverse events occurred, most were related to disease progression rather than the treatment, and preliminary findings indicate that this approach is both feasible and safe, warranting further investigation.