Publications by authors named "S M Elshazly"
Objectives: Hepatotoxicity is a severe outcome of methotrexate (MTX) therapy, limiting its clinical use and contributing to its related morbidity and mortality. This study investigated the hepatoprotective effects of nitazoxanide (NTZ), an antiprotozoal drug, against MTX-induced hepatotoxicity and whether endoplasmic reticulum (ER) stress-modulation underlies the expected beneficial effects of NTZ.
Methods: Thirty-six rats were allocated to six groups, one control group and five MTX groups, where induction of hepatotoxicity was achieved via injecting MTX (20 mg/kg).
This study aimed to examine whether or not aluminum chloride (AlCl)-induced hepatotoxicity might be mitigated using magnetic water (MW) in rats. This study involved 28 adult male rats randomly assigned into the following 4 groups (7 rats/group): normal control (Cnt), MW, AlCl, and Al Cl + MW. The Cnt group orally received normal saline, the MW group drank MW ad libitum for 2 months, and the AlCl and AlCl + MW groups were orally administered AlCl (40 mg/kg b.
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- The study evaluated the expression of five long non-coding RNAs (HOTAIR, MALAT-1, XIST, SNHG15, and H19) in patients with diffuse large B-cell lymphoma (DLBCL) to investigate their relationship with various clinical features.
- Results indicated that HOTAIR was significantly elevated while SNHG15 was downregulated in DLBCL patients, with both showing potential as distinguishing biomarkers between those with DLBCL and healthy individuals.
- The findings suggest that specific lncRNAs could aid in diagnosing and staging DLBCL, as well as predicting patient outcomes, warranting further research to understand their long-term impact on survival and disease progression.
Insulin resistance, induced by high fructose consumption, affects cognitive function negatively. Nifedipine may be suggested for neurological disorders. This study aimed to assess the effect of nifedipine with either a normal diet (ND) or a ketogenic diet (KD) in cognitive dysfunction.
View Article and Find Full Text PDFEpilepsy is a neurological disorder characterized by recurrent spontaneous seizures alongside other neurological comorbidities. Cognitive impairment is the most frequent comorbidity secondary to progressive neurologic changes in epilepsy. Sigma 1 receptors (σ1 receptors) are involved in the neuroprotection and pathophysiology of both conditions and targeting these receptors may have the potential to modulate both seizures and comorbidities.
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