Publications by authors named "S M Ellsworth"
Radiation-induced lymphopenia (RIL) is associated with worse outcomes in patients with multiple solid tumors. Hypofractionated radiation therapy (HFRT) reduces RIL compared with conventionally fractionated radiation therapy (CFRT). However, fractionation effects on immune repertoire (IR) diversity are unknown.
View Article and Find Full Text PDFAbstractSexual dimorphism typically arises as a result of sexual selection or sex-specific natural selection. Species that exhibit cryptic coloration provide an excellent system for studying sex-specific selection for sexual dichromatism. In this study, we examined the sexually dichromatic use of chromatophores in the seawhip shrimp, (Borradaile, 1920), which commonly resides on colonies of (Lamarck, 1815), a gorgonian octocoral that occurs in multiple color morphs.
View Article and Find Full Text PDFArticle Synopsis
- Gene duplication and nucleotide differentiation are key mechanisms for the evolution of new gene functions, particularly in the context of multigene families like those in centipede venom.
- Two hypotheses were tested regarding venom evolution: the two-speed mode, which suggests different selection pressures for ancient and young lineages, and the RAVER model, which attributes amino acid variation based on exposure to solvents rather than lineage age.
- To examine these hypotheses, researchers analyzed venom from 26 centipede species using transcriptomics and proteomics, revealing complex phylogenetic relationships and diverse venom components among the species studied.
Background: While direct oral anticoagulants (DOACs) may be viewed as simpler to manage then warfarin, they present their own unique management challenges resulting in frequent off-label dosing. It is unknown to what extent off-label dosing occurs when a patient is started on a DOAC versus later in their treatment.
Objectives: We aimed to better characterize when off-label DOAC dosing is occurring and to evaluate the effectiveness of prescribing oversight using a registry-based intervention.
Article Synopsis
- - The study investigates how developmental changes in venom expression and diet in eastern diamondback rattlesnakes are linked to age and size, highlighting the unknown molecular mechanisms behind these adaptive traits.
- - Researchers combined genome assembly with expression and epigenomic analysis to discover regulatory elements and transcription factors involved in venom changes, revealing that epigenomic modifications correlate with alterations in gene expression as snakes mature.
- - The findings show that adult snakes have increased expression of transcription factors related to growth and biological timing, indicating a complex gene regulation process that changes venom composition with age, providing insights into broader patterns of life-history evolution across different species.