Publications by authors named "S M El-Morsy"
Article Synopsis
- Carbon quantum dots (CQDs) are flexible nanomaterials used in various applications like diagnostics, sensing, bioimaging, and drug delivery, thanks to their tunable chemical properties.
- This study synthesized lactic acid-derived nitrogen doped CQDs (LAdN-CQDs) and found they can inhibit the formation of toxic fibrils from hen egg-white lysozyme (HEWL) in a dose-dependent manner, achieving up to 50% inhibition.
- LAdN-CQDs showed biocompatibility in neuroblastoma cells by maintaining mitochondrial function and reducing reactive oxygen species, suggesting they may have neuroprotective properties and could be a green chemistry solution in healthcare.
Article Synopsis
- In Egypt, aluminum phosphide (ALP) is a dangerous poison that can lead to death, prompting a study on the predictive value of NT-proBNP for mortality in affected patients.
- The research took place from July to December 2022 at Ain Shams University Hospitals, where patients admitted for ALP poisoning had their NT-proBNP levels, along with other heart-related markers, measured.
- Results showed that non-survivors had significantly higher NT-proBNP levels, with a cutoff point of ≥72 pg/ml being effective for predicting mortality, indicating that NT-proBNP can be an early marker for assessing risk in ALP poisoning cases.
Carbon dots (CDs) are carbon nano materials (CNMs) that find use across several biological applications because of their water solubility, biocompatible nature, eco-friendliness, and ease of synthesis. Additionally, their physiochemical properties can be chemically tuned for further optimization towards specific applications. Here, we investigate the efficacy of C70-derived Graphene Acid Quantum Dots (GAQDs) in mitigating the transformation of soluble, monomeric Hen Egg-White Lysozyme (HEWL) to mature fibrils during its amyloidogenic trajectory.
View Article and Find Full Text PDFThe objective of this paper is to present a novel idea about the continuous possibilistic cooperative static game (Poss-CCSTG). The proposed Poss-CCSTG is a continuous cooperative static game (CCSTG) in which parameter associated with the cost functions of the players involves the possibility measures. The considered Poss-CCSTG is converted into the crisp -CCSTG problem by using the -cuts and hence into the multiple objective nonlinear programming problem.
View Article and Find Full Text PDFCurrently, praziquantel (PZQ) is the only drug of choice used for treatment of human schistosomes because of its safety and broad-spectrum activity. It is reported that the repeated chemotherapy is complicated by the occurrence of drug resistance to schistosomiasis. So there is an urgent need to develop new drug combinations therapy.
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