Publications by authors named "S M Dubinett"

Introduction: Copy-number (CN) loss of chromosome 9p, or parts thereof, impair immune response and confer ICT resistance by direct elimination of immune-regulatory genes on this arm, notably IFNγ genes at 9p24.1, and type-I interferon (IFN-I) genes at 9p21.3.

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The treatment of non-small cell lung cancer has made major strides with the use of immune checkpoint inhibitors, but there remains a significant need for therapies that can overcome immunotherapy resistance. Dendritic cell (DC) vaccines have been proposed as a therapy that can potentially enhance the antitumor immune response. We have embarked on a phase I clinical trial of a vaccine consisting of monocyte-derived DCs (moDCs) modified to express the chemokine CCL21 (CCL21-DC) given in combination with pembrolizumab.

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Article Synopsis
  • Lung cancer remains the leading cause of cancer deaths globally, highlighting the need for better understanding of its early development stages to enable timely interventions.
  • An international team of scientists identified knowledge gaps in how premalignant lung lesions progress to lung cancer and developed research questions to fill these gaps and guide future investigations.
  • Addressing these gaps is crucial for improving screening and early detection methods, which could lead to innovative strategies that effectively reduce lung cancer incidence and enhance patient outcomes.
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Unlabelled: Accurate diagnosis of lung cancer is important for treatment decision-making. Tumor biopsy and histologic examination are the standard for determining histologic lung cancer subtypes. Liquid biopsy, particularly cell-free DNA (cfDNA), has recently shown promising results in cancer detection and classification.

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