Publications by authors named "S M Donath"
Background: Previously it was recognised onset of Lactogenesis II was delayed in women with Type I diabetes compared to women without diabetes, but the effect of gestational diabetes was unclear. Some clinicians suggest pregnant women with diabetes express breastmilk in late pregnancy to hasten onset of Lactogenesis II.
Aims: To confirm if Lactogenesis II occurs later in women with diabetes in pregnancy, and test if advice to express antenatally hastens Lactogenesis II.
Article Synopsis
- - The study evaluates if major management guidelines for extremely preterm infants are effectively applicable to those born before 25 weeks' gestation by reviewing three significant sets of guidelines and their referenced studies.
- - Out of 519 studies analyzed, only about 14.5% of infants were under 25 weeks, with a significant portion of the research, 37.8%, not including any infants from this critical group.
- - The findings conclude that infants born before 25 weeks gestation are underrepresented in the data driving clinical guidelines, highlighting the need for more focused research on this vulnerable population.
Article Synopsis
- Bronchopulmonary dysplasia (BPD) is a serious condition affecting extremely preterm infants, and while systemic corticosteroids can help, they come with risks; inhaled corticosteroids may provide a safer alternative.
- The study aimed to assess the effectiveness of administering budesonide, an inhaled corticosteroid, alongside surfactant in improving survival rates without BPD among extremely preterm infants.
- Conducted across 21 neonatal units in four countries, the trial involved 1,059 infants and found that 25.6% of those receiving budesonide plus surfactant survived without BPD, compared to 22.6% in the surfactant-only group.
Predicting extubation failure in preterm infants using lung ultrasound: a diagnostic accuracy study.
Arch Dis Child Fetal Neonatal Ed
August 2024
Article Synopsis
- A study was done to see how well lung ultrasound (LUS) can predict if preterm babies under 32 weeks will need to be put back on a breathing machine after being taken off.
- The results showed that LUS wasn't very good at predicting this for most babies, but it worked better for extremely preterm babies (born before 28 weeks) and those who were very young (under 72 hours old).
- Researchers think they should study babies who are at high risk of needing to go back on the machine and maybe use simpler ways to check their lungs in the future.
Spatially defined organoid damage enables the study of cellular repair processes. However, capturing dynamic events in living tissues is technically challenging. Here, we present a protocol for the application of single-cell damage in intestinal organoid models.
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