Publications by authors named "S M Dokas"
Allosteric proteins with multiple subunits and ligand-binding sites are central in regulating biological signals. The cAMP receptor protein from Mycobacterium tuberculosis (CRP) is a global regulator of transcription composed of two identical subunits, each one harboring structurally conserved cAMP- and DNA-binding sites. The mechanisms by which these four binding sites are allosterically coupled in CRP remain unclear.
View Article and Find Full Text PDFEndoscopic therapy for postoperative Bergmann type A bile leaks is based on biliary sphincterotomy ± stent insertion. However, recurrent or refractory bile leaks can occur. This was retrospective study including all consecutive patients who were referred to our center with a Bergmann type A bile leak refractory to previous conventional endoscopic treatments.
View Article and Find Full Text PDFBackground: Pancreatic leaks occur as a complication of upper gastrointestinal surgery, acute pancreatitis, or abdominal trauma. Pancreatic fistulas and leaks are primarily managed conservatively. Overall, conservative measures are successful in more than half of cases.
View Article and Find Full Text PDFArticle Synopsis
- Bile leakage often happens after liver surgeries, and treating it can be tricky, especially when the leak comes from small, isolated ducts.
- Traditional methods like surgery can be complicated and risky, so doctors explored new techniques using endoscopy to treat these leaks.
- In a study of 13 patients, doctors used a special procedure to connect the bile flow directly from the isolated duct to the intestine, helping to fix the problem more effectively.