School Ethnic Density and Mental Health Problems in Black, Latine, and White Preadolescent Children.

Objective: Previous studies suggest school ethnic density is associated with less internalizing problems in Black and Latine adolescents in high school. Here, we assessed associations between school ethnic density and internalizing, externalizing, and thought problems in Black, Latine, and White pre-adolescent children (mean age=9.9 years) in elementary school.

Comparative Studies on Bulky DNA Damage Binding by Nucleotide Excision Repair Proteins Using Surface Plasmon Resonance, Differential Scanning Fluorometry, and DNase I Footprinting.

Nucleotide excision repair is a crucial cellular mechanism that ensures genomic stability, thereby preventing mutations that can lead to cancer. The human XPC and its yeast ortholog Rad4 protein complexes are central to this process and were the focus of the study. We used surface plasmon resonance and differential scanning fluorimetry to study the binding characteristics of XPC and Rad4 when bound to the bulky cluster di-FAAF-containing 55-mer duplex DNA.

Increased Emergency Department Medical Imaging: Association with Short-Term Exposures to Ambient Heat and Particulate Air Pollution.

Background Climate change adversely affects human health, resulting in higher demand for health care services. However, the impact of climate-related environmental exposures on medical imaging utilization is currently unknown. Purpose To determine associations of short-term exposures to ambient heat and particulate air pollution with utilization of emergency department medical imaging.

Exploring the Interplay Between Radioimmunoconjugates and Fcγ Receptors in Genetically Engineered Mouse Models of Cancer.

Fcγ receptors (FcγR) are responsible for many of the interactions between immunoglobulins (IgG) and immune cells. In biomedicine, this interplay is critical to the activity of several types of immunotherapeutics; however, relatively little is known about how FcγRs affect the in vivo performance of radiolabeled antibodies. A handful of recent preclinical studies suggest that binding by FcγR-and particularly FcγRI-can affect the pharmacokinetic profiles of Zr-labeled radioimmunoconjugates, but there are no extant studies in immunocompetent or genetically engineered mouse models of cancer.

The Environmental Burden of the United States' Bitcoin Mining Boom.

Bitcoin mines-massive computing clusters generating cryptocurrency tokens-consume vast amounts of electricity. The amount of fine particle (PM) air pollution created because of their electricity consumption, and its effect on environmental health, is unknown. In this study, we located the 34 largest mines in the United States in 2022, identified the electricity-generating plants that responded to them, and pinpointed communities most harmed by Bitcoin mine-attributable air pollution.