Combined Loss of Obsc and Obsl1 in Murine Hearts Results in Diastolic Dysfunction, Altered Metabolism, and Deregulated Mitophagy.

Background: Muscle proteins of the obscurin protein family play important roles in sarcomere organization and sarcoplasmic reticulum and T-tubule architecture and function. However, their precise molecular functions and redundancies between protein family members as well as their involvement in cardiac diseases remain to be fully understood.

Methods: To investigate the functional roles of Obsc (obscurin) and its close homolog Obsl1 (obscurin-like 1) in the heart, we generated and analyzed knockout mice for , , as well as double knockouts.

Antisecretory factor for treatment of peritumoral edema in glioblastoma patients.

Purpose: Glioblastoma (GBM) is an aggressive brain tumor often accompanied by a vasogenic peritumoral edema, which contributes to symptoms both at diagnosis and during later stages of the disease. Previous studies have suggested effectiveness of the endogenous protein, Antisecretory Factor (AF), in reducing the intracranial pressure in cytotoxic brain edema after trauma. Interestingly, AF also seems to carry antineoplastic effects in experimental GBM models.

Tuning Self-Assembly of Hole-Selective Monolayers for Reproducible Perovskite/Silicon Tandem Solar Cells.

Self-assemble monolayers (SAMs) have become state-of-the-art hole-selective contacts for high-efficiency perovskite-based solar cells due to their easy processing, passivation capability, and low parasitic absorption. Nevertheless, for the deposition of SAMs with a monolayer thickness and a high packing density on metal oxide substrates, critical challenges persist. To overcome these, the study focuses on the impact of annealing temperature - an intrinsic yet so far unexplored process parameter - during the formation of SAMs.

Barriers and drivers to COVID-19 protective behaviours of forcibly displaced myanmar nationals (FDMN)/ rohingya refugees in Cox's bazar, Bangladesh: A scoping review.

About 900.000 Forcibly Displaced Myanmar Nationals (FDMN)/ Rohingya refugees live in makeshift camps in Cox's Bazar, Bangladesh. During the COVID-19 pandemic, protective behaviors were particularly important in this setting of previous severe infectious disease outbreaks.

Continuous Stitches Versus Simple Interrupted Stitches During Anterior Colporrhaphy: A Randomized Controlled Trial.

The anterior vaginal wall is frequently affected by prolapse, which is frequently treated with anterior colporrhaphy. However, this repair has a high recurrence rate, and no standardized approach exists. Our study aimed to compare two suture techniques concerning postoperative outcomes.