Validation of a Coarse-Grained Martini 3 Model for Molecular Oxygen.

Molecular oxygen (O) is essential for life, and continuous effort has been made to understand its pathways in cellular respiration with all-atom (AA) molecular dynamics (MD) simulations of, e.g., membrane permeation or binding to proteins.

The level of cognitive functioning in school-aged children is predicted by resting EEG Directed Phase Lag Index.

Quantifying cognitive potential relies on psychometric measures that do not directly reflect cortical activity. While the relationship between cognitive ability and resting state EEG signal dynamics has been extensively studied in children with below-average cognitive performances, there remains a paucity of research focusing on individuals with normal to above-average cognitive functioning. This study aimed to elucidate the resting EEG dynamics in children aged four to 12 years across normal to above-average cognitive potential.

Evaluation of the Activity of Vogt-Koyanagi-Harada Disease; A Comparison of Indocyanine Green Angiography Scoring, Enhanced Depth Imaging Optical Coherence Tomography, and Choroidal Vascularity Index.

Purpose: To investigate the correlation between choroidal biomarkers using enhanced depth imaging optical coherence tomography (EDI-OCT) and indocyanine green angiography (ICGA) scoring for monitoring the activity of Vogt-Koyanagi-Harada (VKH).

Methods: Patients who were not in the acute phase of VKH were recruited. Simultaneous EDI-OCT and ICGA were captured in seven patients only at baseline, in six patients at the 3-month follow-up, and in two patients at both the 6- and 9-month follow-ups.

Understanding Oxygen "Buffering" by Caveolae Using Coarse-Grained Molecular Dynamics Simulations.

The "oxygen paradox" embodies the delicate interplay between two opposing biological processes involving oxygen (O). O is indispensable for aerobic metabolism, fuelling oxidative phosphorylation in mitochondria. However, excess O can generate reactive species that harm cells.