Simultaneous Live Mapping of pH and Hydrogen Peroxide Fluctuations in Autophagic Vesicles.

Hydrogen peroxide (HO) plays a critical role in the regulation and progress of autophagy, an essential recycling process that influences cellular homeostasis and stress response. Autophagy is characterized by the formation of intracellular vesicles analogous to recycle "bags" called autophagosomes, which fuse with lysosomes to form autolysosomes, eventually ending up as lysosomes. We have developed two novel autophagic vesicle-targeted peptide-based sensors, for HO and for pH, to simultaneously track HO and pH dynamics within autophagic vesicles as autophagy advances.

Tunable structural rearrangement in Cu cluster assemblies through linker and solvent alterations.

The scarcity of approaches to assembling copper nanoclusters (Cu NCs) has restricted advancements in Cu NCs research, largely due to stability challenges of the individual NCs. By utilizing the structural adaptability of Cu NCs, we systematically investigate how variations in organic linkers and solvents affect the cluster node size, shape, and their assembling dimensionality. Here, we introduce a facile, one-pot synthesis method for obtaining a range of crystalline Cu cluster-assembled materials (CAMs) through a liquid-liquid interfacial crystallization technique.

Effects of Women's Participation in Household Decision Making on Skilled Birth Attendants Supervised Delivery in Bangladesh.

Background: While the importance of women's participation in household decision making in enhancing access to healthcare services is widely acknowledged, limited evidence exists on the link between women's participation in household decision making and skilled birth attendants (SBA) supervised delivery. This study aims to fill this gap by examining the effects of women's participation in household decision making on SBA supervised delivery in Bangladesh.

Methods: Data of 3607 mothers who had given birth within 2 years of the survey date were extracted from the 2022 Bangladesh Demographic and Health Survey (BDHS) and analyzed.

Green materials in semiconductors: perspective from the IRDS Beyond-CMOS roadmap.

Environmental, Safety, Health, and Sustainability (ESHS) have become an indispensable issue in the semiconductor industry. The "Beyond CMOS" chapter of the International Roadmap for Devices and Systems(IRDS) roadmap introduces the concept of "Green materials", emphasizing their importance for maintaining sustainability in semiconductor manufacturing. We discuss the current trends of emerging architectures and devices in the perspective of "Green materials".

A comprehensive insights of cancer immunotherapy resistance.

Cancer is a major global health issue that is usually treated with multiple therapies, such as chemotherapy and targeted therapies like immunotherapy. Immunotherapy is a new and alternative approach to treating various types of cancer that are difficult to treat with other methods. Although immune checkpoint inhibitors have shown promise for long-term efficacy, they have limited effectiveness in common cancer types such as breast, prostate, and lung.