Publications by authors named "S M Costa"
The MCF-7R breast cancer cell line, developed by treating the parental MCF-7 cells with increasing doses of doxorubicin, serves as a model for studying acquired multidrug resistance (MDR). MDR is a major challenge in cancer therapy, often driven by overexpression of the efflux pump P-glycoprotein (P-gp) and epigenetic modifications. While many P-gp inhibitors show promise in vitro, their nonspecific effects on the efflux pump limit in vivo application.
View Article and Find Full Text PDFPurpose: To compare postoperative outcomes of bedside surgery (BS) with those of surgery performed in the operating room (ORS) in preterm and full-term neonates.
Methods: Data from neonates undergoing major surgical interventions were retrospectively evaluated. Primary outcome was the incidence of postoperative hypothermia.
Objectives: Atopic/allergic diseases impose a growing burden on public health, affecting millions of patients worldwide. The main objective of this study was to develop a national expert consensus on relevant clinical questions related to type 2 inflammation.
Methods: We conducted: a comprehensive literature review with a qualitative analysis to identify the most repeated themes on the overlap of conditions; a modified 3-round Web-Delphi (or e-Delphi); and a final online decision conference.
Article Synopsis
- Embracing local knowledge is crucial for biodiversity conservation, but there is a lack of effective frameworks to incorporate this knowledge properly.
- Using a Wisdom of Crowds approach, the study tested whether diverse groups of individuals, with varying ages and fishing experience, provided better estimates of fishing quality compared to more uniform groups.
- The research found that targeting a diverse group of 31% of survey participants captured most unique responses; small diverse groups were as effective as larger ones in assessing ecological conditions, highlighting the importance of including varied knowledge holders in research.