Publications by authors named "S M Cooley"
Objective: To assess the relationship between postoperative opioid consumption and frailty status.
Background: Physiologic reserve can be assessed through both chronologic age as well as measures of frailty. Although prior studies suggest that older individuals may require less opioid following surgery, chronologic age, and frailty do not always align, and little is known regarding postoperative opioid consumption patterns by frailty.
Veterans Aging Cohort Study Index 2.0 Shows Improved Discrimination of Neurocognitive Impairment and Frailty in People with HIV.
J Acquir Immune Defic Syndr
September 2024
Objective: This study examined whether the revised VACS2.0 index (including serum albumin, body mass index (BMI), and white blood cell (WBC) count) had stronger correlations with cognitive function, brain volume, and frailty in PWH ≥ 50 years compared to the VACS1.0.
View Article and Find Full Text PDFInitial Experience with Lecanemab and Lessons Learned in 71 Patients in a Regional Medical Center.
J Prev Alzheimers Dis
November 2024
Article Synopsis
- The FDA approved lecanemab (Leqembi®) on July 6, 2023, for treating mild cognitive impairment or mild dementia caused by Alzheimer's disease, with early experiences shared from a regional medical center.
- A retrospective study at the Norton Neuroscience Institute Memory Center involved 71 patients, all diagnosed with Alzheimer’s through cerebrospinal fluid biomarkers, most of whom were older, predominantly female, and referred by their primary care providers.
- The study found that 24% of patients experienced amyloid-related imaging abnormalities (ARIA) after treatment, with differences noted between those homozygous and heterozygous for the ApoE4 genotype.
Article Synopsis
- - The 14th International Workshop on HIV and Aging, held on October 26-27, 2023, focused on improving health span for people living with HIV (PWH) by exploring issues related to aging and comorbid conditions.
- - Key topics included the biology and treatment of sarcopenia, long-acting antiretroviral therapy (ART), and complications related to the central nervous system, along with mental health and social factors.
- - Presentations emphasized the need for prioritizing mental health care, addressing loneliness, and conducting research on resilience among PWH to tackle ongoing challenges.