Publications by authors named "S M Collin"
Background: Cardiomyocytes in the adult human heart show a regenerative capacity, with an annual renewal rate of ≈0.5%. Whether this regenerative capacity of human cardiomyocytes is employed in heart failure has been controversial.
View Article and Find Full Text PDFIn the open ocean, achieving camouflage is complicated by the fact that the downwelling light is generally much brighter than the upwelling light, which means that any object, even if its ventral surface is white due to countershading, will appear as a dark silhouette when viewed from below. To overcome this, many marine species employ counterillumination, whereby light is emitted from photophores on their ventral surface to replace the downwelling light blocked by their body. However, only a single behavioral study has tested the efficacy of counterillumination as an anti-predation strategy.
View Article and Find Full Text PDFBackground: Language and cultural discordance refer to when a physician and patient do not share the same language or culture. This can create barriers to providing high-quality care at the end-of-life (EoL). This study explores the intersections of language, culture, geography, and care model in EoL care from the perspectives of palliative care physicians.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on how enzymes, specifically HMG-CoA synthase (HMGCS), have evolved to take on new roles in polyketide biosynthesis, which involves a different substrate interaction than their traditional function.
- Researchers used techniques like X-ray crystallography and small-angle X-ray scattering to show that an HMGS from the virginiamycin system is more flexible compared to its typical counterparts, which is crucial for its ability to handle larger substrates.
- Findings highlight the importance of combining different structural biology methods since existing models like AlphaFold2 failed to accurately predict the enzyme's structural transitions when binding to its natural substrates.
Article Synopsis
- The study aimed to analyze attrition rates from first-line to third-line therapies in patients with HER2-positive metastatic breast cancer across several European countries.
- It found that 29.6% of patients discontinued treatment after first-line therapy and 34.2% after second-line therapy, often due to death or transition to palliative care.
- Additionally, the time patients remained on treatment decreased with each line of therapy, indicating diminishing effectiveness of subsequent treatments.