Comparison of the effects of standard vs low-dose prolonged-release tacrolimus with or without ACEi/ARB on the histology and function of renal allografts.

Targeting the renin-angiotensin system and optimizing tacrolimus exposure are both postulated to improve outcomes in renal transplant recipients (RTRs) by preventing interstitial fibrosis/tubular atrophy (IF/TA). In this multicenter, prospective, open-label controlled trial, adult de novo RTRs were randomized in a 2 × 2 design to low- vs standard-dose (LOW vs STD) prolonged-release tacrolimus and to angiotensin-converting enzyme inhibitors/angiotensin II receptor 1 blockers (ACEi/ARBs) vs other antihypertensive therapy (OAHT). There were 2 coprimary endpoints: the prevalence of IF/TA at month 6 and at month 24.

Why take the chance? A qualitative grounded theory study of nocturnal haemodialysis recipients who decline kidney transplantation.

Objective: The objective of this study was to examine the factors that influence decision-making to forgo transplantation in favour of remaining on nocturnal haemodialysis (NHD).

Design: A grounded theory approach using in-depth telephone interviewing was used.

Setting: Participants were identified from 2 tertiary care renal programmes in Canada.

Levofloxacin for BK virus prophylaxis following kidney transplantation: a randomized clinical trial.

Importance: BK virus infection is a significant complication of modern immunosuppression used in kidney transplantation. Viral reactivation occurs first in the urine (BK viruria) and is associated with a high risk of transplant failure. There are currently no therapies to prevent or treat BK virus infection.

Stability of risky driving from late adolescence to early adulthood.

This study examined the stability of risky driving behaviour from late adolescence to early adulthood among 823 young Australian drivers participating in an ongoing longitudinal study. This issue was explored by examining the stability of risky driving between the ages of 19-20 and 23-24 years (1) across the cohort and (2) among individuals. Focusing on cohort-wide trends, a modest reduction in the occurrence of speeding was observed across the sample between 19-20 and 23-24 years.

Quinolone prophylaxis for the prevention of BK virus infection in kidney transplantation: study protocol for a randomized controlled trial.

Background: BK virus infection has emerged as a major complication in kidney transplantation leading to a significant reduction in graft survival. There are currently no proven strategies to prevent or treat BK virus infection. Quinolone antibiotics, such as levofloxacin, have demonstrated activity against BK virus.