An antibody cocktail targeting two different CD73 epitopes enhances enzyme inhibition and tumor control.

CD73, an ectoenzyme responsible for adenosine production, is often elevated in immuno-suppressive tumor environments. Inhibition of CD73 activity holds great promise as a therapeutic strategy for CD73-expressing cancers. In this study, we have developed a therapeutic anti-human CD73 antibody cocktail, HB0045.

Understanding water reaction pathways to control the hydrolytic reactivity of a Zn metal-organic framework.

Metal-organic frameworks (MOFs) are a class of porous materials that are of topical interest for their utility in water-related applications. Nevertheless, molecular-level insight into water-MOF interactions and MOF hydrolytic reactivity remains understudied. Herein, we report two hydrolytic pathways leading to either structural stability or framework decomposition of a MOF (ZnMOF-1).

Specific Monitoring the DNA Helicase Function via Anchor-Embedded DNA Probe.

DNA helicases play a pivotal role in maintaining genome integrity by unwinding the DNA double helix and are often considered promising targets for drug development. However, assessing specific DNA helicase activity in living cells remains challenging. Herein, the first anchor-embedded duplex (ATED) probe, 17GC, is constructed to uniquely monitor the unwinding activity of Werner syndrome helicase (WRN), a clinical anticancer target.

Childhood and Adolescent Overweight/Obesity Prevalence Trends in Jiangsu, China, 2017-2021: An Age-Period-Cohort Analysis.

Objectives: To investigate temporal trends in childhood and adolescent overweight/obesity in Jiangsu Province, China, evaluating the effects of age, period, and birth cohort.

Design: Cross-sectional study.

Sample: Participants were 210,168 students aged 6-17 years from the five waves of the consecutive cross-sectional Jiangsu provincial surveillance project in 2017-2021.

Multi-Functional Semiconductor Polymer Doped Wide Bandgap Layer for All-Perovskite Solar Cells with High Efficiency and Long Durability.

The study presents a multi-functional and semiconductor polymer poly[bis(3-hexylthiophen-2-yl)thieno[3,4-c]pyrrole-4,6-dione] (PBDTTPD) doping strategy that significantly enhanced the performance of the two-terminal all-perovskite tandem perovskite solar cells (T-PSCs). An optimized power conversion efficiency (PCE) of 26.87% has been achieved.