Publications by authors named "S M Bijukchhe"
Introduction: Giant urinary bladder stones are rare phenomenon which is associated with chronic urinary infections, intravesical foreign bodies, urethral strictures, bladder diverticula etc. CASE REPORT: A 52-year-old man presented with complaints of severe dysuria, urgency, frequency, suprapubic pain, and pollakuria for the last ten years. Physical examination revealed a palpable suprapubic mass with no obvious flank masses.
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- - Results showed that the Vi-typhoid conjugate vaccine (Vi-TT) is highly effective in generating immune responses in children under 16, especially when administered at 9 months of age compared to 12 months.
- - The study involved 50 children who received the vaccine at either 9 or 12 months, with significant differences in antibody response, particularly after the booster dose at 15 months—100% seroconversion in the 9-month group versus 0% in the 12-month group.
- - The findings suggest that a longer interval between vaccine doses leads to a stronger immune response, supporting the use of Vi-TT for early immunization against typhoid.
Nepal had its worst dengue outbreak in 2022. Climate change, urbanization and increased transportation networks have favoured dengue mosquito vectors. As the monsoon season approaches, dengue outbreak seems inevitable.
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- The OptImms trial aims to evaluate the effectiveness of adjusted vaccination schedules that can accommodate new vaccines for infants while maintaining adequate antibody levels against pertussis and other diseases.
- Conducted in Nepal and Uganda, this study involves randomizing infants into different groups based on various factors like the timing and number of diphtheria-tetanus-pertussis (DTP) vaccine doses, with the main outcome being the measurement of antibodies against pertussis at booster doses.
- The results of this research will help guide future policies for childhood vaccination schedules, potentially leading to more efficient immunization practices globally.
Article Synopsis
- The study aims to assess the effectiveness of COVID-19 vaccines used in Nepal (inactivated, viral vector, mRNA) and investigate infections with variants of SARS-CoV-2 in a hospital setting.
- It involves a hospital-based case-control design where patients over 18 with COVID-19-like symptoms undergo antigen/PCR testing, collecting data on vaccine status and demographics to determine vaccine effectiveness.
- Ethical approvals were secured from relevant institutions, ensuring a thorough and responsible approach to understanding vaccine efficacy and variant circulation in Nepal, aiming to enhance public health strategies.