Precipitation drives western Patagonian glacier variability and may curb future ice mass loss.

Two-thirds of all glaciers worldwide are projected to disappear by 2100 CE. Large uncertainties however remain in maritime settings, where some glaciers have recently gained mass in response to increased snowfall. One of these regions is southern Patagonia, where increased precipitation since the 1980s seems to have attenuated glacier retreat.

Saving Time Saves Lives: Optimizing Radio Dispatching in Out-of-Hospital Cardiac Arrests.

Objective Activation of emergency medical services (EMS) through radio dispatching in the United States of America is the established first component in the link of the Chain of Survival. However, little is known about how auditory dispatch alerts operationally aid in the recognition and physical response of priority dispatch communications. This research aims to determine if a modification in radio alerting procedures will elicit a reduction in chute times for first responders.

Therapeutic efficacy of the BKCa channel opener chlorzoxazone in a mouse model of Fragile X syndrome.

Fragile X syndrome (FXS) is an X-linked neurodevelopmental disorder characterized by several behavioral abnormalities, including hyperactivity, anxiety, sensory hyper-responsiveness, and autistic-like symptoms such as social deficits. Despite considerable efforts, effective pharmacological treatments are still lacking, prompting the need for exploring the therapeutic value of existing drugs beyond their original approved use. One such repurposed drug is chlorzoxazone which is classified as a large-conductance calcium-dependent potassium (BKCa) channel opener.

Innovative molecular networking analysis of steroids and characterisation of the urinary steroidome.

Steroids are cholesterol-derived biomolecules that play an essential role in biological processes. These substances used as growth promoters in animals are strictly regulated worldwide. Targeted assays are the conventional methods of monitoring steroid abuse, with limitations: only detect known metabolites.