Advancements in bone malignancy research through next-generation sequencing focussed on osteosarcoma, chondrosarcoma, and Ewing sarcoma.

Next-generation sequencing (NGS) technologies have revolutionized bone cancer research, enabling detailed insights into the genetic, transcriptional, and epigenetic layers of these malignancies. This overview discusses the pivotal role of NGS in enhancing the diagnosis, prognosis, and treatment of primary bone cancers such as osteosarcoma, chondrosarcoma, and Ewing sarcoma. By facilitating the identification of novel genetic mutations, gene fusions, and epigenetic alterations, NGS supports the development of personalized medicine approaches and targeted therapies, significantly impacting clinical outcomes.

Radioanatomical characteristics of zygoma for planning of quad zygoma implants: a cross sectional study.

Purpose: To evaluate the radioanatomical measurements of the zygoma as a guide for treatment planning of quad zygomatic implant placement.

Methods: This cross sectional study was carried on 17 patients of 34 zygomatic regions reported with atrophic maxilla for placement of zygomatic implants. The zygomatic implants were placed virtually in a quad approach using "Real Guide" version 3.

Neuroimmune interactions between itch neurons and skin microbes.

Itch is an unpleasant sensation that is encoded by specific sensory neurons called pruriceptors. Itch is associated with almost all skin diseases. Recent studies revealed that many itchy skin diseases are associated with microbiome dysbiosis.

Following changes in brain structure and function with multimodal MRI in a year-long prospective study on the development of Type 2 diabetes.

Aims: To follow disease progression in a rat model of Type 2 diabetes using multimodal MRI to assess changes in brain structure and function.

Material And Methods: Female rats ( = 20) were fed a high fat/high fructose diet or lab chow starting at 90 days of age. Diet fed rats were given streptozotocin to compromise pancreatic beta cells, while chow fed controls received vehicle.

Review of rhythm disturbances in patient after fontan completion: epidemiology, management, and surveillance.

Purpose: The Fontan operation is commonly associated with alterations in heart rhythms, both tachycardic and bradycardic. Despite modifications to attempt to mitigate these complications, arrythmias still frequently occur. The purpose of this review is to examine the literature regarding the scope of the problem, therapeutic options, and current recommendations regarding screening and surveillance.