Social and Legal Needs in Patients and Families With Cancer: Interaction With Patient-Level Financial Toxicity.

Adverse financial burden and its effect on patients resulting from the costs associated with cancer care, both direct and indirect, is known as financial toxicity. This review explores the interplay between financial toxicity and key social and legal needs in cancer care. Drawing from the WHO's framework and the ASCO's policy statement on social determinants of health, we propose a conceptual model that discusses five key needs-housing insecurity, food insecurity, transportation and access barriers, employment disruptions, and psychosocial needs-which interact with, and are affected by financial toxicity, and adversely influence patients' well-being and adherence to treatment.

Impaired spatial coding and neuronal hyperactivity in the medial entorhinal cortex of aged mice.

The progressive accumulation of amyloid beta (Aβ) pathology in the brain has been associated with aberrant neuronal network activity and poor cognitive performance in preclinical mouse models of Alzheimer's disease (AD). Presently, our understanding of the mechanisms driving pathology-associated neuronal dysfunction and impaired information processing in the brain remains incomplete. Here, we assessed the impact of advanced Aβ pathology on spatial information processing in the medial entorhinal cortex (MEC) of 18-month knock-in (APP KI) mice as they explored contextually novel and familiar open field arenas in a two-day, four-session recording paradigm.

Increasing Incidence of Coronary Artery Disease in Younger Men: Case Study of a 39-Year-Old.

Coronary artery disease (CAD) is the leading cause of death globally. While it is usually diagnosed after years of declining health or after a myocardial infarction (MI), we found that patients can be asymptomatic, posing a latent and life-threatening risk. We present the case of a man less than 40 years old, in whom heart disease was incidentally discovered during a CT scan performed for an unrelated condition.

High-Risk Credit Borrowing Patterns: A Comparison of Cancer With Major Chronic Diseases.

Purpose: Although financial toxicity from cancer care is well documented, how cancer and other high-mortality chronic diseases affect credit overuse and high-risk borrowing remains unknown.

Methods: We retrospectively analyzed households in the 2012-2018 Health and Retirement Study. Outcomes included nonhousing financial debt and credit card debt.