Publications by authors named "S M Al-Rawashdeh"
Article Synopsis
- Cardiovascular diseases, particularly hereditary Long QT Syndrome (LQTS), are linked to ion channel dysfunctions, leading to a higher risk of sudden cardiac death, especially with the LQT2 type caused by mutations in the hERG gene.
- Specific high-affinity hERG blockers like E-4031 could potentially rescue these dysfunctional channels, but the mechanisms behind their effectiveness are unclear.
- The study employs accelerated molecular dynamics simulations to show how mutations in the hERG channel alter its structure and trafficking, and suggests that E-4031 may inhibit these detrimental changes, paving the way for new treatments targeting the underlying cellular issues.
Background: The World Health Organization recommended the use of chemical-based disinfectants as an effective prevention of the COVID-19 pandemic. However, calls for poisoning were reported in several medical centers. The widespread use of chemical-based disinfectants as a preventive measure during the COVID-19 pandemic has underscored potential gaps in community awareness and performance, posing health risks.
View Article and Find Full Text PDFIllness Anxiety Disorder and Distress among Female Medical and Nursing Students.
Clin Pract Epidemiol Ment Health
November 2023
Article Synopsis
- This study investigates the prevalence of illness anxiety disorder (IAD) and stress among medical and nursing students at a Saudi Arabian university, highlighting differences in their anxiety levels and characteristics.
- Data was collected from 216 medical and 250 nursing students using measurement tools for assessing health anxiety and distress.
- Results indicated that nursing students displayed a higher prevalence of IAD (57.2%) compared to medical students (17.6%), suggesting a need for enhanced mental health support in both disciplines to mitigate potential impacts on academic performance and future careers.
Small colloidally aggregating molecules (SCAMs) can be problematic for biological assays in drug discovery campaigns. However, the self-associating properties of SCAMs have potential applications in drug delivery and analytical biochemistry. Consequently, the ability to predict the aggregation propensity of a small organic molecule is of considerable interest.
View Article and Find Full Text PDFThe aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that mediates biological signals to control various complicated cellular functions. It plays a crucial role in environmental sensing and xenobiotic metabolism. Dysregulation of AhR is associated with health concerns, including cancer and immune system disorders.
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