Publications by authors named "S M Al-Khatib"

Implantable cardioverter-defibrillators (ICDs) are recommended to reduce the risk of sudden cardiac death (SCD) in patients with heart failure with reduced ejection fraction (HFrEF). The landmark studies leading to the current guideline recommendations preceded the 4 pillars of guideline-directed medical therapies (GDMTs). Therefore, some have questioned the role of ICDs for primary prevention in current clinical practice.

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Speckle-type POZ (SPOP) is described as an essential tumor suppressor factor in gastric cancer, colorectal cancer, and prostate cancer (PCa). SPOP gene mutations were reported in primary human PCa. Isocitrate dehydrogenase-1 (IDH1) oncogene mutations were detected in gliomas, acute myeloid leukemia, some benign and malignant cartilaginous tumors, and only 1% of PCa.

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Article Synopsis
  • * This study examined 484 patients with psychiatric disorders in Jordan, finding that 30.8% had undiagnosed hypertension, with higher prevalence among males and those on specific medications (SNRIs).
  • * Key risk factors for undiagnosed hypertension included older age, higher body mass index, and a family history of cardiovascular diseases, highlighting the need for better hypertension screening in mental health patients.
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Background: Despite an elevated risk of sudden cardiac death among dialysis patients, implantable cardioverter defibrillators (ICDs) have not been shown to improve mortality and are associated with high complication rates. Subcutaneous (S-)ICDs may reduce the risk of complications for eligible dialysis patients, but safety and benefits vs transvenous (TV-ICDs are unknown.

Objective: To compare long-term outcomes between dialysis patients receiving S-ICD vs TV-ICDs.

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