Publications by authors named "S M Abrams"
Purpose: Rodent models suggest that when respiratory demands increase during an exercise program, tongue and thyroarytenoid muscles engage to maintain a patent airway, leading to increased muscle strength. This suggests that nonspecific exercises that increase respiratory rate may improve swallowing. As such, the purpose of this proof-of-principle study was to determine the potential for whole-body exercise to improve tongue strength, cough strength, and self-reported swallowing function in older adults with Parkinson's disease (PD).
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- The study investigates how resistance to PD-L1 inhibitors affects interferon (IFN) signaling and influences secretory changes in tumor cells.
- It identifies a specific tumor secretome (PTIS) induced by anti-PD-L1 treatment, which can suppress T cell activation and reduce the effectiveness of immune response against tumors.
- The research emphasizes the need for in vivo resistance models to better understand treatment failures, as the tumor's adaptive secretory changes regulated by type I IFNs play a significant role in evading immune attacks.
Objective: Growth faltering is widespread in many low- and middle-income countries, but its effects on childhood bone mass accrual are unknown. The objective of this study was to estimate associations between length (conditional length-for-age -scores, cLAZ) and weight (conditional weight-for-age -scores, cWAZ) gain in three age intervals (ages 0-6, 6-12 and 12-24 months) with dual-energy X-ray absorptiometry-derived measures of bone mass (total body less head (TBLH) bone mineral content (BMC), areal bone mineral density (aBMD) and bone area) at 4 years of age.
Design: Associations between interval-specific growth parameters (cLAZ and cWAZ) and bone outcomes were estimated using linear regression models, adjusted for maternal, child and household characteristics.
Article Synopsis
- COVID-19 vaccine effectiveness decreases over time, prompting the possibility of repeated booster shots, but many are concerned about side-effects versus benefits.
- This study focuses on identifying common side-effects, their duration, and predicting the likelihood of experiencing moderate-to-severe side-effects after booster vaccinations using data from Belgian health care providers.
- Results showed that 11% of participants experienced moderate-to-severe side-effects post-booster, with fatigue and pain being the most frequent, and side-effects usually lasting 1 to 2 days.