Publications by authors named "S M A Kawsar"
Aim: There is an urgent need for new antimicrobial compounds with alternative modes of action for the treatment of drug-resistant bacterial and fungal pathogens.
Background: Carbohydrates and their derivatives are essential for biochemical and medicinal research because of their efficacy in the synthesis of biologically active drugs.
Objective: In the present study, a series of methyl α-D-mannopyranoside (MMP) derivatives (2-6) were prepared via direct acylation, and their biological properties were characterized.
Article Synopsis
- - Researchers isolated a new lectin, named hRTL, from a marine sponge, which belongs to the galectin family and shows high similarity to another galectin called CCL.
- - hRTL is a tetramer composed of 141 amino acids and features a unique 23 amino acid signal peptide that gets cleaved after translation, differing from most galectins which usually have acetylated modifications.
- - The hRTL lectin binds strongly to specific glycan structures and has been shown to induce cytotoxic effects in colorectal cancer cells expressing certain antigens, suggesting potential therapeutic implications.
This work describes the synthesis, characterization, and in vitro and in silico evaluation of the biological activity of new functionalized isoxazole derivatives. The structures of all new compounds were analyzed by IR and NMR spectroscopy. The structures of and were further confirmed by single crystal X-ray and their compositions unambiguously determined by mass spectrometry (MS).
View Article and Find Full Text PDFCarbohydrate derivatives play a crucial roles in biochemical and medicinal research, especially in the fields of chemistry and biochemistry. From this perspective, the present study was designed to explore the synthesis of methyl α-D-glucopyranoside derivatives (1-8), focusing on their efficacy against bacterial and fungal inhibition. The structure of the synthesized compounds was ascertained using FTIR, H-NMR, C-NMR, mass and elemental analyses.
View Article and Find Full Text PDFArticle Synopsis
- - SeviL, a lectin from mussels, has been shown to induce apoptosis in HeLa ovarian cancer cells and promote M1 polarization in macrophage cell lines at low concentrations.
- - Low levels of SeviL decrease the growth of monocyte and basophil cell lines but stimulate proliferation in RAW264.7 macrophages, evidenced by changes in cell shape and up-regulation of mitochondrial proteins.
- - Treatment with SeviL leads to increased secretion of pro-inflammatory cytokines and activation of various signaling pathways, indicating its role in regulating cell behaviors like proliferation and death in macrophages, which may impact immune responses in living organisms.