Association between risk of Alzheimer's disease and related dementias and angiotensin receptor Ⅱ blockers treatment for individuals with hypertension in high-volume claims data.

Background: Findings regarding the protective effect of Angiotensin II receptor blockers (ARBs) against Alzheimer's disease and related dementias (AD/ADRD) and cognitive decline have been inconclusive.

Methods: Individuals with hypertension who do not have any prior ADRD diagnosis were included in this retrospective cohort study from Optum's de-identified Clinformatics® Data Mart. We identified antihypertensive medication (AHM) drug classes and subclassified ARBs by blood-brain barrier (BBB) permeability.

On the Maximum Obtainable Purity and Resultant Maximum Useful Membrane Selectivity of a Membrane Separator.

Design considerations concerning the maximum purity of a membrane separator, and the resultant maximum effective selectivity of the membranes were explored by modeling a binary gas membrane separator (pressure-driven permeance) using a dimensionless form. Although the maximum purity has an analytical solution at the limit of zero recovery or stage cut, this solution over-predicts the obtained purity as the recovery is increased. Furthermore, at combinations of high recovery, low feed mole fraction, and low pressure ratio, the maximum purity becomes independent of selectivity above some critical selectivity.

Drug utilization among young adults with atopic dermatitis: Influence of sex, socio-economic status and disease severity.

Background: Atopic dermatitis (AD) affects individuals of all ages, and the first-line treatment are emollients and topical corticosteroids. There is insufficient knowledge about factors possibly affecting the drug utilization of young adults with AD.

Objectives: To describe the drug utilization of young adults with AD in relation to sex, socio-economic status and disease severity.