Copy Number Variations in Short Tandem Repeats Modulate Growth Traits in Penaeid Shrimp Through Neighboring Gene Regulation.

Penaeid shrimp, with its genomes enriched in short tandem repeats (STRs), presents an ideal model for studying the distribution and biological functions of STRs. In this study, we systematically identified and compared STRs across multiple species, confirming a significantly higher prevalence of STRs (26-32%) in penaeid shrimp, which is markedly higher than that observed in other species, such as mammals (1.3-2.

Comparative analysis of persistent and recanalized falcine sinuses on magnetic resonance venography: insights from healthy individuals and parasagittal meningioma patients.

Background: Falcine sinuses can remain persistent after birth, but they can also become recanalized in cases where venous sinuses are invaded by meningiomas.

Purpose: To explore the incidence and imaging features of persistent falcine sinuses in healthy individuals and recanalized falcine sinuses in parasagittal meningioma (PSM) patients on magnetic resonance venography (MRV).

Material And Methods: Radiologists evaluated imaging data of 168 healthy individuals and 168 PSM patients.

Genomic selection strategies to overcome genotype by environment interactions in biosecurity-based aquaculture breeding programs.

Background: Family-based selective breeding programs typically employ both between-family and within-family selection in aquaculture. However, these programs may exhibit a reduced genetic gain in the presence of a genotype by environment interactions (G × E) when employing biosecurity-based breeding schemes (BS), compared to non-biosecurity-based breeding schemes (NBS). Fortunately, genomic selection shows promise in improving genetic gain by taking within-family variance into account.

Prenatal phenotype of PNKP-related microcephaly, seizures, and developmental delay: A case report and literature review.

Rationale: Microcephaly, epilepsy, and developmental delay (MCSZ) is a rare neurodevelopmental disorder associated with autosomal recessive inheritance of mutations in the polynucleotide kinase 3'-phosphatase (PNKP) gene. Prompt identification and management are essential, as delayed diagnosis or intervention may result in severe complications or mortality. In this case, prenatal screening in the second trimester detected fetal microcephaly with a gradual decline in head circumference, prompting the decision to terminate the pregnancy.

A data-driven framework for developing a unified density-modulus relationship for the human lumbar vertebral body.

Despite the broad agreement that bone stiffness is heavily dependent on the underlying bone density, there is no consensus on a unified relationship that applies to both cancellous and cortical compartments. Bone from the two compartments is generally assessed separately, and few mechanical test data are available for samples from the transitional regions between them. In this study, we present a data-driven framework integrating experimental testing and numerical modeling of the human lumbar vertebra through an energy balance criterion, to develop a unified density-modulus relationship across the entire vertebral body, without the necessity of differentiation between trabecular and cortical regions.