Effects of antioxidants on DNA-double strand breaks in human gingival fibroblasts exposed to methacrylate based monomers.

Objective: (Co)monomers from dental resin composites have cytotoxic and genotoxic potential. In previous studies it has been demonstrated that antioxidants can decrease the cytotoxicity of various dental (co)monomers. In this study the effects of the antioxidants N-acetylcysteine (ACC) and ascorbic acid (Asc) on the number of DNA double-strand breaks (DSBs) in human gingiva fibroblasts (HGFs) were tested.

Induction of DNA double-strand breaks by monochlorophenol isomers and ChKM in human gingival fibroblasts.

Phenol has been traditionally used in dental treatment as a sedative for the pulp or as disinfectant for carious cavity and root canal. However, phenol is regarded as a mutagenic and carcinogenic agent and its use in dental practice is now therefore restricted. Monochlorophenols are derivatives of phenol, which are still used clinically as root canal disinfectants, they are even more active antiseptics/disinfectants than phenol, and the so-called Walkhoff (ChKM) solution makes use of monochlorophenol for root canal disinfection.

Identification of two new Dichelobacter nodosus strains in Germany.

The multi-strain anaerobe Dichelobacter nodosus causes footrot, a contagious disease of the digits of ruminants that occurs worldwide. Eleven D. nodosus-like isolates from footrot lesions of sheep in Germany were investigated by PCR amplification of the variable region of the D.