Publications by authors named "S Lorkowski"
Article Synopsis
- The study examined how serum levels of minerals and phosphate relate to overall and cardiovascular death rates, especially in patients with varying kidney functions.
- Low levels of sodium and iron were linked to worse kidney performance and higher death risks, while higher zinc levels correlated with lower risks.
- Those with kidney functions below 60 mL/min faced a fourfold increase in mortality risk, emphasizing the need for regular monitoring of serum minerals and kidney health in cardiovascular patients.
Scope: The α-tocopherol long-chain metabolite α-tocopherol-13'-hydroxy-chromanol (α-T-13'-COOH) is a proposed regulatory intermediate of endogenous vitamin E metabolism. Effects of α-T-13'-COOH on cell viability and adaptive stress response are not well understood. The present study aims to investigate the concentration-dependent effects of α-T-13'-COOH on cellular redox homeostasis, genotoxicity, and cytotoxicity in murine RAW264.
View Article and Find Full Text PDFThis study aimed to estimate the association between single dietary risk factors and cardiovascular mortality in the WHO European Region, its four subregions and 46 individual countries. For this purpose, data from the Global Burden of Diseases Study (GBD) 2019 iteration were employed and analysed according to age (≥ 25 years) and sex. The comparative risk assessment framework of the GBD was utilized in order to estimate the number of cardiovascular deaths that could be attributed to 13 dietary risks.
View Article and Find Full Text PDFBackground: Homozygous mutations in the APOA5 gene constitute a rare cause of monogenic hypertriglyceridemia, or familial chylomicronemia syndrome (FCS). We searched PubMed and identified 16 cases of homozygous mutations in the APOA5 gene. Severe hypertriglyceridemia related to monogenic mutations in triglyceride-regulating genes can cause recurrent acute pancreatitis.
View Article and Find Full Text PDFArticle Synopsis
- Hypertriglyceridemia and type 2 diabetes are major global metabolic issues, heavily influenced by diet.
- A 10-week study involved 136 subjects with elevated triglyceride or glucose levels, where intervention groups received customized meal plans and support, while control groups followed a Western diet.
- Significant improvements were observed in blood lipids, glucose levels, and body weight in intervention groups, with some benefits lasting through follow-up, showcasing the effectiveness of targeted dietary changes.