Publications by authors named "S Longobardi"
Background: Intensive physical activity and rigid dietary regimes can act as modifiers of neuroendocrine axes in women, inducing hormonal disorders and related menstrual irregularities such as functional hypothalamic amenorrhea (FHA). It would be important to evaluate if such disturbances may worsen female fertility. The aim of this study was to evaluate ovarian reserve markers and neuroendocrine axis in young military academy female cadets with years of training and occurrence of FHA.
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- A panel of international experts evaluated and discussed the POSEIDON criteria, aiming to improve management strategies for women with low prognosis in assisted reproductive technology (ART).
- Through a Delphi consensus process involving multiple rounds of voting, 53 experts reviewed 17 statements and reached consensus on their relevance for patient care and outcomes in ART.
- Key recommendations include using specific treatments and tools to enhance success rates, while emphasizing the need for more large-scale studies to validate existing findings.
Article Synopsis
- The clinical management of women with diminished ovarian reserve (DOR) poses challenges, particularly due to inconsistent definitions of DOR across studies.
- This research aims to evaluate various adjuvant treatments for women with DOR based on the POSEIDON criteria, analyzing data from numerous studies published until June 2024.
- The analysis includes 38 randomized controlled trials, identifying testosterone supplementation as a treatment associated with higher live birth rates in women with DOR compared to those who did not receive supplementation.
Female fertility depends on the ovarian reserve of follicles, which is determined at birth. Primordial follicle development and oocyte maturation are regulated by multiple factors and pathways and classified into gonadotropin-independent and gonadotropin-dependent phases, according to the response to gonadotropins. Folliculogenesis has always been considered to be gonadotropin-dependent only from the antral stage, but evidence from the literature highlights the role of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) during early folliculogenesis with a potential role in the progression of the pool of primordial follicles.
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- - Erythema multiforme (EM) is a skin condition that can occur due to infections, medications, vaccines, or autoimmune diseases, with NSAIDs like ibuprofen having rare associations with it and resultant pancytopenia (low blood cell counts).
- - A 75-year-old woman developed EM and pancytopenia after taking ibuprofen for shoulder bursitis, presenting with neck swelling, a target-shaped rash, and oral ulcers 15 days post-medication.
- - After discontinuing ibuprofen and providing supportive care, including blood transfusions, the patient’s condition improved, and she was discharged six days later, highlighting the need for awareness of rare NSAID side effects among healthcare professionals.