Publications by authors named "S Lochynski"

Article Synopsis
  • Researchers are investigating new antimicrobial agents for use in perfumery to meet market and legislative demands, testing 53 low molecular oximes and their carbonyl counterparts.
  • The most effective compound identified was α-isomethylionone oxime, with a minimum inhibitory concentration (MIC) of 18.75 µg/mL against Enterococcus hirae.
  • ADME-Tox analysis and MTS cell viability tests showed that the selected compounds were safe and non-toxic to human kidney cells, suggesting their potential as non-toxic antibacterial agents.
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Cyanobacteria are characterized by a very high tolerance to environmental factors. They are found in salt water, fresh water, thermal springs, and Antarctic waters. The wide spectrum of habitats suitable for those microorganisms is related to their particularly effective metabolism; resistance to extreme environmental conditions; and the need for only limited environmental resources such as water, carbon dioxide, simple inorganic salts, and light.

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Terpenoids with lactone moieties have been indicated to possess high bioactivity. Certain terpenoid lactones exist in nature, in plants and animals, but they can also be obtained by chemical synthesis. Terpenoids possessing lactone moieties are known for their cytotoxic, anti-inflammatory, antimicrobial, anticancer, and antimalarial activities.

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Incorporation of the Beckmann rearrangement into the presented research resulted in the formation of nitrogen-containing terpenoid derivatives originating from naturally occurring compounds. Both starting monoterpenes and obtained derivatives were subjected to estimation of their antibacterial potential. In the presented study, was the most sensitive to examined compounds.

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In the synthesis performed in this study, derivatives of 4-tert-butylcyclohexanone 1 were obtained using typical reactions of organic synthesis. The bioactivity of the selected compounds was evaluated. 1-(Bromomethyl)-8-tert-butyl-2-oxaspiro[4.

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