Publications by authors named "S Lo Presti"
Background: Notwithstanding guidance from the European Cystic Fibrosis (CF) Society (ECFS) neonatal screening (NBS) working group, significant variation persists in the evaluation and management of Cystic Fibrosis Screen Positive, Inconclusive Diagnosis (CFSPID) subjects, leaving many aspects of care under debate. This study reports the results of a national survey investigating management and treatment approaches of pre-school CFSPIDs in Italy.
Methods: In February 2024, a comprehensive questionnaire was distributed to all Italian CF centers.
Objective: This retrospective study aimed to analyze the clinical characteristics, ventilatory strategies, and effectiveness of ventilation in pediatric patients with central apneas treated at the Sleep Medicine and Long-Term Ventilation Unit of the Bambino Gesù Children's Hospital in Rome from 2012 to 2022.
Methods: Among all ventilated patients at our Center from January 2012 to December 2022, we retrospectively included children with a cAHI ≥ 1 events/h on baseline poly(somno)graphic study. Additional parameters assessed included the underlying disease, type of ventilation (non-invasive vs.
EBV infection alters DNA methylation in primary human colon cells: A path to inflammation and carcinogenesis?
Biochim Biophys Acta Gene Regul Mech
December 2024
Article Synopsis
- Epstein-Barr Virus (EBV) is linked to various cancers, particularly affecting epithelial cells, and is associated with changes in DNA methylation that contribute to cancer development.
- In previous research, EBV was shown to infect human colonic cells, causing inflammation and tumor growth, which could be reduced by stopping viral replication.
- The current study explores how EBV infection alters DNA methylation in human colonic cells, with findings indicating a greater prevalence of hypermethylation affecting genes related to cancer, inflammation, and embryonic development.
Article Synopsis
- The study investigates how our brains associate small and large numbers with spatial positions (left for smaller, right for larger) using fMRI technology and a go/no-go task.
- It found that this space-number association (SNA) only appeared when tasks were framed in a joint-code format, where participants responded faster to congruent conditions (e.g., small number with left arrows).
- The research highlights that SNA is linked to increased brain activity and connectivity in specific regions, suggesting that the association is driven by top-down cognitive processes rather than an inherent spatial coding of numbers.